The movie revolves around Jayamohan, a business magnate, who leads a hectic life. Things start going topsy-turvy when he gets married to Anjali. He begins facing problems that affect his business as well. Lailaa-o-Lailaa is the second collaboration of the Joshiy-Mohanlal-Amala trio after the success of Run Baby Run. Renowned Bollywood scriptwriter Suresh Nair of Kahaani fame debuts in Malayalam with the film.