Malini 22 Palayamkottai story begins with Malini (nithya) who works as a nurse in Chennai. She hails from Palayamkottai. As most nurses want, she decides to go to Canada and takes the help of the consultant Varun (krish). In no time, both get close and at one point Malini gets physically intimate with Varun. The story takes a turn when Varun ends up having a fight with the son of a big official and he goes into hiding. But Malini has a mystery guest at her home and that changes her life. What happens from there forms the rest.