Margarita With a Straw story is about Shubhangini (revathi) is a devoted mother to her child Laila (kalki) who suffers from cerebral palsy and is wheelchair bound. But Laila is stubborn headed and doesn’t believe she is disabled. However, she is great at creative writing and does a good job for a rock band. She also falls in love with a band member Nima (tenzing) but he doesn’t love her. Heartbroken, Laila goes to New York for course in writing along with Shubhangini and what happens from there forms the rest.