The story of Gayatri is quite routine and is set amidst an haunted house on the outskirts of Hyderabad. Sanjay(Satyam Rajesh) and his girlfriend Sandhya(Sushma Raj) decide to get away from the city to have a good time during the weekend.As they begin their journey, some unwanted incidents happen and the couple end up taking shelter in this haunted house. Unaware of the fact that the entire bungalow is possessed by an evil spirit called Gayatri(Trisha), the couple start settling down.As expected, Gayatri starts getting behind their lives and keeps scaring them to death. Who is this Gayatri ? What does she have to do with the haunted house ? and how do the couple survive this chaos ? That form the rest of the story.