No One Killed Jessica story begins on the backdrop of the capital city Delhi and here is the beautiful and aspiring model Jessica (myra). However, her dreams are shortlived as she is shot dead in a celebrity party. The killer is Manish (Md zeeshan), son of a influential politician Pramod Bharadwaj (shireesh sharma) and he does the act in totally drunk state. The reason- Jessica refuses to serve drinks since the bar is closed. Manish is taken in and in no time, he is acquitted despite the presence of 300 guests in that party. However, Jessica's sister Sabrina (vidya) takes the mantle and she is supported by a rough tongued and determined lady journalist Meera (rani) to bring the killer to justice. What happens from there forms the rest of the story.