Trisha Illana Nayanthara is completely an adult comedy film. Lead actor GV Prakash who is essaying as the lead in this film has lot of friends in his circle, and he shares his birthday with two girls who are born in same place. All these friends celebrate the birthday party and grow up together. One fine day, GV Prakash falls in love with one of the girls (Anandhi) in his friend’s circle.But due to inability in keeping up his secrets, his first love fails. After that, Prakash’s concentration deviates to another girl and he falls in love with her. Interestingly the second girl is exactly opposite his first girl friend. After knowing that, she is too hot and modernity to handle, he leaves that girl. The entire story is mixed up with the loads of adult comedy.