Vaayai Moodi Pesavum story begins with Aravind (dulquer) a salesman who believes that problems can be solved easily if both sides talk transparently. On the other side, there is a village which is struck by dumb flu wherein people lose their voice and sometimes die. This place is attended by a doctor Anjana (nazriya) who has an over possessive boyfriend. With the flu spreading the government declares that no one should talk in that area. What happens from there forms the rest.